| 16:20 - 16:30 | Welcome |
| 16:30 - 18:30 |
Session 1: Prokaryotic Argonaute proteins (pAgos) |
| 16:30 - 17:00 |
Daan Swarts
The diverse functions and mechanisms of prokaryotic Argonaute proteins
|
| 17:00 - 17:30 |
Dina Grohmann*
Structural and functional insights into DNA silencing by an archaeal Argonaute variant
|
| 17:30 - 18:00 |
Alexei Aravin
Diversity of Argonaute functions in prokaryotes and cooperation between distinct Ago-mediated pathways in animals
|
| 18:00 - 18:15 |
Balwina Koopal (short talk)
Short prokaryotic Argonaute systems trigger cell death upon detection of invading DNA
|
| 18:15 - 18:30 |
Mindaugas Zaremba (short talk)
Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion |
| 18:30 - 19:00 |
Posters Sneak Peek
|
| 19:00 - ... |
Welcoming Mixers |
| 8:30 - 10:30 | Session 2: Argonaute proteins in plants and plant pathogens |
| 8:30 - 9:00 |
Nicolás Bologna
ARGONAUTE shuttling mechanisms in plants
|
| 9:00 - 9:30 |
Peter Brodersen*
Distinction between small RNA-bound and free ARGONAUTE via an N-terminal protein-protein interaction site
|
| 9:30 - 9:45 |
Andrea Martín-Merchán (short talk)
Post-translational modifications of ARGONAUTEs in Arabidopsis
|
| 9:45 - 10:15 |
Xuemei Chen
Argonaute proteins in plants
|
| 10:15 - 10:30 |
An-Po Cheng (short talk)
Argonautes in plant-pathogen interactions
|
| 10:30 - 11:00 | Coffee break |
| 11:00 - 12:50 |
Session 3: Piwi proteins in different organisms |
| 11:00 - 11:30 |
Phillip Zamore
Adventures with the Argonautes
|
| 11:30 - 12:00 |
Yukihide Tomari
The two Gtsf paralogs in silkworms orthogonally activate their partner PIWI proteins for target cleavage
|
| 12:00 - 12:30 |
Claus Kuhn*
The role of piRNAs in planarian stem cells and their potential role in immune defence
|
| 12:30 - 12:45 |
Srinivasa Abishek Prakash (short talk)
piRNA-guided DNA methylation relies on DNMT3C to antagonize H3K4me3 at transposon promoters
|
| 12:45 - 12:50 |
Anda Pitiriciu – Proteintech (sponsoring)
|
| 12:50 - 14:00 | Lunch |
| 14:00 - 15:00 | Poster session |
| 15:00 - 18:45 |
Session 4: Argonaute proteins in nematodes |
| 15:00 - 15:30 |
Amy Pasquinelli
Less stress with microRNAs
|
| 15:30 - 16:00 |
Julie Claycomb
Argonomics: A systematic study of C. elegans Argonautes
|
| 16:00 - 16:30 |
Martin Simard
Function and regulation of miRNA-specific Argonautes
|
| 16:30 - 17:00 |
Coffee break
|
| 17:00 - 17:30 |
Germano Cecere
Epigenetic maintenance of animal fertility by piRNAs in C. elegans
|
| 17:30 - 18:00 |
Amy Buck*
Evolution and function of an extracellular Argonaute protein in parasitic nematodes: probing cross species RNA interference in mice
|
| 18:00 - 18:30 |
Charles Nelson
Rethinking microRNA-mediated regulation of lin-28 in the C. elegans heterochronic network
|
| 18:30 - 18:45 |
Meetali Singh (short talk)
Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
|
| 19:00 - ... | Dinner, get together |
| 8:30 - 11:00 | Session 5: Argonaute proteins: A structure-function view |
| 8:30 - 9:00 |
Ian MacRae
The hidden molecular dance underlying RNA slicing by Argonaute
|
| 9:00 - 9:30 |
Kotaro Nakanishi*
Global microRNA trimming generates their tiny RNAs
|
| 9:30 - 10:00 |
Stefan Ameres
tba
|
| 10:00 - 10:30 |
Carolien Bastiaanssen
A next-generation single-molecule technique: Elucidating the sequence effect on Argonaute target binding
|
| 10:30 - 10:45 |
Sarah Willkomm (short talk)
Single-molecule FRET measurements uncover conformational dynamics of human Argonaute 2 in its apo form and during its catalytic cycle
|
| 10:45 - 11:00 |
Andrew Walsh (short talk)
Argonaute base preferences elucidated from RNAi screens
|
| 11:00 - 11:30 | Coffee break |
| 11:30 - 18:30 |
Session 6: Argonaute proteins in mammals |
| 11:30 - 12:00 |
Constance Ciaudo
Argonaute proteins regulate nuclear processes in mESCs
|
| 12:00 - 12:30 |
Petr Svoboda
Strange AGO variants in mammalian oocytes
|
| 12:30 - 12:45 |
Simone Larivera
Differences and similarities between AGO2- and YTHDF2-mediated gene regulation
|
| 12:45 - 14:00 | Lunch |
| 14:00 - 15:00 | Poster session |
| 15:00 - 15:30 |
David Bartel
Target-directed microRNA degradation
|
| 15:30 - 16:00 |
Matthew Poy
Glutamatergic Argonaute2 regulates formation of the neurovascular unit
|
| 16:00 - 16:30 |
Michael Kiebler
RNP assembly in neurons with a focus on Ago proteins
|
| 16:30 - 17:00 |
Coffee break
|
| 17:00 - 17:30 |
David Corey
Relocation of Argonaute protein to cell nuclei in cultured cells grown to high density and in human tumors
|
| 17:30 - 18:00 |
Joana Vidigal*
AGO2 silences mobile transposons in the nucleus of quiescent cells
|
| 18:00 - 18:15 |
Lisa Linck-Paulus (short talk)
A new Argonaute 2 splice variant modulates cell viability and impacts microRNA function in melanoma cells
|
| 18:15 - 18:30 |
Iwona Nowak (short talk)
Development of novel proximity-directed labelling-based technique for studying subcellular RNAi
|
| 18:30 - ... | Joined conference dinner with the participants of the Argonautes syndrome conference |
| 8:30 - 10:30 | Session 7: Disease-associated Argonaute mutations |
| 8:30 - 9:00 |
Amélie Piton*
Unique and recurrent de novo variants in the AGO1 gene cause a neurodevelopmental disorder with intellectual disability, autism, and motor delay
|
| 9:00 - 9:30 |
Anna Zinovyeva
Modelling neurodevelopmental disorders-associated hAGO1 mutations in C. elegans Argonaute ALG-1 reveals miRNA functional impairment, mutation-specific changes in miRNA populations, and global shifts in gene expression profiles
|
| 9:30 - 10:00 |
Davor Lessel
Identification, clinical and molecular characterization of individuals affected by Lessel-Kreienkamp syndrome
|
| 10:00 - 10:30 |
Hans-Jürgen Kreienkamp
Functional characterization of AGO2 variants identified in individuals affected by Lessel-Kreienkamp syndrome
|
| 10:30 - ... |
End of scientific meeting and session with patient families, interested researchers and lay people of the city of Regensburg. Includes keynote lecture by Dr. Leslie Gordon who drove development of a treatment for ultra-rare disease Progeria, and a panel with families sharing their experience. |
